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Safety and efficacy of daclatasvir in the management of patients with chronic hepatitis C

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Safety and efficacy of daclatasvir in the management of patients with chronic hepatitis C (EN)
Zissis, Miltiadis
Zacharakis, George
Giannakopoulos, Vassilis
Manolakopoulos, Spilios
Daclatasvir (Daklinza™), a new oral direct-acting antiviral, is an inhibitor of hepatitis C virus NS5A protein and has recently been approved in the United States, Europe and Japan in chronic hepatitis C. It shows potent pangenotypic activity and moderately high genetic barrier to resistance improving the sustained virological response (SVR) rates. In COMMAND phase 2 trials, daclatasvir demonstrated high SVR rates in HCV genotype 1-4 chronically infected patients treated with peginterferon-α (pegIFNα) plus ribavirin (RBV). Furthermore, it produced even higher response rates in all-oral combination with sofosbuvir, an interferon-free regimen, with or without ribavirin, in patients with advanced liver disease, HCV/HIV coinfection, liver transplantation in ALLY studies and other real-world studies. This narrative review provides information on the pharmacological properties, role, efficacy and safety of daclatasvir-containing regimens in chronic hepatitis C patients. Daclatasvir administered once-daily in combination with sofosbuvir is an effective 12-week treatment in adult patients with chronic hepatitis C and is generally safe and well tolerated.Keywords Daclatasvir, chronic hepatitis C, treatmentAnn Gastroenterol 2016; 29 (3): 282-296 (EN)
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Hellenic Society of Gastroenterology
Annals of Gastroenterology
Review Articles
English
2016-06-27
http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2604
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 29, No 3 (2016); 282 (EN)



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