Current noninvasive modalities in Crohn’s disease monitoring

This item is provided by the institution :
Hellenic Society of Gastroenterology   

Repository :
Annals of Gastroenterology   

see the original item page
in the repository's web site and access all digital files if the item*



Current noninvasive modalities in Crohn’s disease monitoring (EN)

Katsanos, Konstantinos H.
Mitselos, Ioannis V.
Lamouri, Charikleia
Fousekis, Fotios S.
Christodoulou, Dimitrios K.

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

2021-11-20


Crohn’s disease (CD) is characterized by a remitting and relapsing course. Longstanding active CD may result in accumulating intestinal damage and disease-related complications. In contrast, mucosal healing is associated with significant improvement in the health-related quality of life, longer periods of disease remission and lower risk of disease progression, complications, hospitalizations, intestinal surgeries, as well as a lower risk of developing colorectal cancer. Mucosal healing, the new treatment endpoint in CD, made necessary the development of noninvasive, accurate, objective and reliable tools for the evaluation of CD activity. Ileocolonoscopy with biopsies remains the reference standard method for the evaluation of the colonic and terminal ileal mucosa. However, it is an invasive procedure with a low risk of complications, allowing the investigation of only a small part of the small bowel mucosa without being able to assess transmural inflammation. These disadvantages limit its role in the frequent follow up of CD patients. In this review, we present the currently available biomarkers and imaging modalities for the noninvasive assessment of CD activity. Keywords Crohn’s disease, monitoring, disease activity Ann Gastroenterol 2021; 34 (6): 770-780 (EN)

English

Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 34, No 6 (2021); 770 (EN)

Copyright (c) 2021 Annals of Gastroenterology (EN)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)