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Evaluating the effect of various background correction methods regarding noise reduction, in two-channel microarray data

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Evaluating the effect of various background correction methods regarding noise reduction, in two-channel microarray data
Chatziioannou, A. A.
Prentza, A.
Koutsouris, D.
Article
2012-10-01
2012-01
2012-10-01T15:25:08Z
In this work, two novel background correction (BC) methods, along with several commonly used ones, are evaluated regarding noise reduction in eleven two-channel self-versus-self (SVS) hybridizations. The evaluation of each BC method is investigated under the use of four statistical criteria combined into a single measure, the polygon area measure. Overall, our proposed BC approaches perform very well in terms of the proposed measure for most of the cases and provide an improved effect regarding technical noise reduction.
English
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Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Ινστιτούτο Bιολογίας, Φαρμακευτικής Χημείας και Βιοτεχνολογίας (ΙΒΦΧΒ)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)
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Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
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