Ebenfurans IV-VIII from Onobrychis ebenoides: Evidence that C-Prenylation is the Key Determinant of the Cytotoxicity of 3-Formyl-2-arylbenzofurans

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Title

Ebenfurans IV-VIII from Onobrychis ebenoides: Evidence that C-Prenylation is the Key Determinant of the Cytotoxicity of 3-Formyl-2-arylbenzofurans

Creator

Aligiannis, Necktarios

Alexi, Xanthippi

Alexis, Michael N.

Skaltsounis, Alexios-Leandros

Type

Article

Journal part (EN)

Scientific article (EN)

Date

2012-10-01

2012-10-01T15:25:10Z

2008-11

Year

2008 (EN)

Description

Phytochemical investigation of a methanol extract of Onobrychis ebenoides yielded five new 3-formyl-2-arylbenzofurans, namely, ebenfurans IV-VII (1-5), together with the known compounds ebenfurans I, II (6), and III (7). Only 1 and 7 exhibited growth inhibitory activity against MCF-7 and Ishikawa cells, suggesting that the prenyl moiety at position C-5 is the key determinant of the cytotoxic activity of this group of compounds.

Language

English

Source

Τύποι Τεκμηρίων

Άρθρο σε περιοδικό

Συλλογές του Ήλιος

Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)

Ινστιτούτο Bιολογίας, Φαρμακευτικής Χημείας και Βιοτεχνολογίας (ΙΒΦΧΒ)

Provider

National Hellenic Research Foundation (NHRF)

Repository / collection

Helios - Repository of the National Hellenic Research Foundation (NHRF)