9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini

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Title

9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini

Creator

Roussis, Vassilios

Vagias, Constantinos

Alexi, Xanthippi

Abdel-Razik, Ayman F.

Alexis, Michael N.

Description

Four new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spectroscopic analysis. Metabolites 1 and 2 were found to strongly inhibit the growth of LNCaP human prostate adenocarcinoma cells and the estrogen-dependent growth of MCF-7 human breast adenocarcinoma cells.

Type

Article