5 alpha,8 alpha-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity

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Title

5 alpha,8 alpha-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity

Creator

Roussis, Vassilios

Vagias, Constantinos

Christofidis, Dimitrios

Alexi, Xanthippi

Abdel-Razik, Ayman F.

Zervou, Maria

Alexis, Michael N.

Description

Three new (1, 4, 9) and nine previously reported (2, 3, 5-8, 10-12) 5 alpha,8 alpha-epidioxysterols were isolated from the organic extracts of the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum. The structures and relative configurations of 1-12 were established on the basis of detailed NMR spectroscopic analyses and comparison with the literature. The growth inhibitory effects of 1-12 were evaluated against MCF-7 human breast cancer cells. Compound 1, bearing a cyclopropyl moiety in the side chain, exhibited the highest antiproliferative activity.

Type

Article