Transition metal complexes of new glyoxylato-aroylhydrazones and their role in L-ascorbic acid oxidation inhibition

This item is provided by the institution :
National Hellenic Research Foundation (NHRF)

Repository :
Helios - Repository of the National Hellenic Research Foundation (NHRF) | repositories EKT

see the original item page
in the repository's web site and access all digital files if the item^*

Title

Transition metal complexes of new glyoxylato-aroylhydrazones and their role in L-ascorbic acid oxidation inhibition

Creator

Raptopoulou, Catherine P.

Villalonga-Barber, Carolina

Steele, Barry R.

Psycharis, Vassilis

Description

We report here the synthesis of new ligands of the aroylhydrazone family. Glyoxylato-aroylhydrazones (gly-AH) with lipophilic character were designed for possible biological applications where metal chelation is desired. They were found to coordinate readily with a number of metals and the crystal structures of the copper and zinc complexes, M(py)(2)L (M = Cu, Zn): LH2 (L2) = N'-(2-hydroxy-3-(pentan-3-yl)benzylidene)-2-mesity1-2-oxoacetohydrazide have been determined. The complexes both display a distorted trigonal bipyramidal coordination geometry around the metals. Ascorbate oxidase and ascorbate peroxidase mimicking reactions were carried out to determine the ability of the title ligands to inhibit metalinduced oxidation of L-ascorbic acid via complexes generated in situ.

Type

Article