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Sustained and Extended Release with Structural and Activity Recovery of Lysozyme from Complexes with Sodium (Sulfamate Carboxylate) Isoprene/Ethylene Oxide Block Copolymer

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Sustained and Extended Release with Structural and Activity Recovery of Lysozyme from Complexes with Sodium (Sulfamate Carboxylate) Isoprene/Ethylene Oxide Block Copolymer
Πίσπας, Στέργιος
Yan, Yunfeng
Yao, Ping
Gao, Gao
Άρθρο σε επιστημονικό περιοδικό
2010-02-11
Weinheim
The complexation of lysozyme and sodium (sulfamate carboxylate) isoprene/ethylene oxide (SCIEO) at pH = 7.4 and the release of lysozyme from the complexes in the presence of NaCl were investigated. Through electrostatic and hydrophobic interactions, lysozyme and SCIEO form stable complex nanoparticles. The complexation partially disturbs the structure of lysozyme. Some of the hydrophobic residues of lysozyme are exposed to bind with SCIEO. The complexation leads to loss of most of the lysozyme activity. In the presence of NaCl, lysozyme can be released from the complexes. The released lysozyme molecules recover their native structure and activity completely. In the condition A of physiological pH and ionic strength, a sustained and extended release of lysozyme was achieved.
Βιολογία (Γενικά) (EL)
Επιστήμη (Γενικά) (EL)
Τεχνολογία (Γενικά) (EL)
Biology (General) (EN)
Technology (General) (EN)
Science (General) (EN)
drug delivery systems
nanoparticles
Materials Science, Biomaterials
proteins
diblock copolymers
Polymer Science
polyelectrolytes
English
Wiley-v C H Verlag Gmbh
Macromolecular Bioscience
https://rightsstatements.org/page/InC/1.0/?language=en
© WILEY-V C H VERLAG GMBH
© WILEY-V C H VERLAG GMBH (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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