1. Home page
  2. Search

Effect of histamine on the signal transduction of the AtoS–AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli

This item is provided by the institution :
National Hellenic Research Foundation (NHRF)   

Repository :
Helios - Repository of the National Hellenic Research Foundation (NHRF)  | repositories EKT   

see the original item page
in the repository's web site and access all digital files if the item*



Effect of histamine on the signal transduction of the AtoS–AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli
Filippou, P. S.
Tiligada, E.
Kyriakidis, K. D.
Theodorou, M. C.
AtoS-AtoC two-component system acts directly on the atoDAEB operon transcription to regulate the biosynthesis of short-chain poly-(R)-3- hydroxybutyrate. This study sought to investigate the effect of histamine and compound 48/80 on the regulation of AtoS-AtoC two-component system in Escherichia coli K-12 MA255 (speC -, speB -) and the isogenic E. coli strains BW25113 (atoSC +) and BW28878 (ΔatoSC) transformed with plasmids carrying related genes. Histamine or compound 48/80 induced or tended to reduce atoC transcription, respectively, while neither compound showed any effect on atoDAEB operon transcription. Moreover, histamine down-regulated poly-(R)-3-hydroxybutyrate biosynthesis, whereas compound 48/80 up-regulated its biosynthesis, maximal induction being obtained in the presence of multiple copies of AtoS-AtoC. Interestingly, co-administration of histamine counteracted this inductive effect of compound 48/80. The reported data provide the first evidence for a differential modulator role of histamine and compound 48/80 on the AtoS-AtoC two-component system signaling in potentially pathogenic bacteria, leading to a new perspective on their symbiotic behavior. © 2008 Springer-Verlag.
Article
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)
Άρθρο σε περιοδικό
EC_fundedresources set
Driver
Video
Άλλες Συλλογές
English
2008
2012-06-12T12:22:58Z
2008-12-11T09:21:54Z
DOI: http://dx.doi.org/10.1007/s00726-007-0635-8
http://hdl.handle.net/10442/7914
Τύποι Τεκμηρίων
Άλλες Συλλογές
Άρθρο σε περιοδικό
Συλλογές του Ήλιος



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)