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Metal-ligand interaction in molecular imprinted polymers for C-terminal cholecystokinin pentapeptide

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Metal-ligand interaction in molecular imprinted polymers for C-terminal cholecystokinin pentapeptide
Liakopoulou-Kyriakides, M.
Papi, R.M.
Kyriakidis, D.A.
Inspired by the rich diversity of non-covalent interactions occurring in nature, researchers have pursued artificial receptors preparation by molecular imprinting technology. Recognition sites in molecularly imprinted polymers (MIPs), in case of non-covalent approach, are created by the polymerization of preorganized functional monomers around the template with weak interactions, leading to broad distribution of specific binding sites. The metal-coordination interactions are quite directional, therefore very promising to MIPs design. The well defined coordination sphere of many transition metals complexes allows control of the orientation of functionality in MIPs, offering a high degree of versatility in targeting different functional groups in many biologically molecules. The production of MIPs for the recognition of C-terminal cholecystokinin pentapeptide (CCK-5, NH2-Gly- Trp-Met-Asp-Phe-CONH2) in the presence of metal ion is reported. The MIPs were produced under the same molar ratio of template to monomers (acrylamide, N, N￠-methylene bisacrylamide and 4-vinylpyridine) in the presence or absence of nitrilotriacetic acid–nickel (Ni– NTA) complex and their rebinding characteristics, net rebinding, imprinting factor and Lagmuir absorption constants, are reported.
Article
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)
Άρθρο σε περιοδικό
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Άλλες Συλλογές
English
2008
2008-12-11T09:21:59Z
2012-06-12T12:23:05Z
http://hdl.handle.net/10442/7929
DOI: http://dx.doi.org/10.1111/j.1742-4658.2008.06448.x
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Άλλες Συλλογές
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