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Bacterial signaling and adaptation

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Bacterial signaling and adaptation
This special issue seeks to summarize the state-of-theart and to explore novel aspects of signaling and adaptation in bacteria by portraying well-characterized examples, thus adding new promising perspectives in the physiological significance and potential exploitation of signaling pathways. Since diverse systems display a number of operating principles in common, the study of one signaling system, such as the amine-sensing two-component system AtoSC, can yield insights applicable to others. Understanding the structural and biophysical properties of many two-component systems provides the potential to enhance their rational engineering and to correlate their evolution with behavioral phenotypes and ecological niche occupancy. Moreover, transport proteins may act as transmitters of information from the cytoplasmic membrane to the subsequent signaling components. Accessory proteins appear to act in concert with their cognate two-component systems, thus defining novel three-component systems, such as the bacterial oxidative stress-response pathway involving HbpS and SenS-SenR. The complicated signaling networking is further exemplified by the secondary active transporter BetP, which responds to hyperosmotic stress by increased transcription mediated via MtrAB. Although bacteria largely employ two-component system-mediated phosphorylation, a new family of BY-kinases comes into the regulatory play in bacterial cells. Finally, elucidating bacterial physiology may provide alternative beneficial end points in therapeutic strategies, such as bacterial cancer therapy targeting primary and metastatic tumors, through preferential bacterial promoter activation.
Article
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)
Άρθρο σε περιοδικό
EC_fundedresources set
Driver
Video
Άλλες Συλλογές
English
2009-09
2010-04-21T10:01:51Z
2012-06-12T12:23:00Z
http://hdl.handle.net/10442/8328
DOI: http://dx.doi.org/10.1007/s00726-009-0272-5
Τύποι Τεκμηρίων
Άλλες Συλλογές
Άρθρο σε περιοδικό
Συλλογές του Ήλιος



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