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Peptidomimetic–functionalized carbon nanotubes with antitrypsin activity

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Peptidomimetic–functionalized carbon nanotubes with antitrypsin activity
Siskos, Argiris
Papi, Rigini M.
Glezakos, Petros
Tagmatarchis, Nikos
Sarigiannis, Yiannis
Vakalopoulou, Paraskevi
Kyriakidis, D.A.
Stavropoulos, Georgios
Water-soluble functionalized carbon nanotubes (CNTs) have been prepared and further conjugated through a stable covalent bond with two peptidomimetics. The structural design of the covalently grafted peptidomimetics to the CNTs is based on their structural similarity with the metabolites of antagonist G of substance P. A variety of analytical spectroscopic methods, in combination with electron microscopy and thermal analysis, aided the structural and morphological characterization of the four newly synthesized peptidomimetic–CNT conjugates. It is demonstrated that the trypsin inhibitory effect of the peptidomimetic–CNT is enhanced as a result of the high-loading of peptidomimetics onto the skeleton of the modified water-soluble CNTs. Additionally, the peptidomimetic– functionalized CNT conjugates can be recovered and re-employed up to six biological evaluation cycles showing the same trypsin inhibitory activity. Such a nanosized system is extremely advantageous for the inhibition of inflammation or malignancy and could find potential future biological applications in the area of drug delivery systems.
Article
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)
Άρθρο σε περιοδικό
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Video
Άλλες Συλλογές
English
2009-12
2010-04-23T08:07:45Z
2012-06-12T12:22:57Z
http://hdl.handle.net/10442/8335
DOI: http://dx.doi.org/10.1016/j.carbon.2009.08.025
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Άλλες Συλλογές
Άρθρο σε περιοδικό
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