Paraneoplastic cerebellar degeneration in platinum-responsive
endometrial cancer: A case report and review of literature
Liontos, Michalis
Fiste, Oraianthi
Drakopoulou, Danai and
Thomakos, Nikolaos
Goula, Kalliroi
Zagouri, Flora and
Anagnostouli, Maria
Dimopoulos, Meletios-Athanasios
Paraneoplastic cerebellar ataxia is a rare immune-induced,
non-metastatic neurologic syndrome, most frequently associated with
gynecological cancers, which carries an abysmal prognosis. We report the
case of a patient with advanced-stage uterine cancer, who developed
severe pancerebellar ataxia, while in partial remission, after the
completion of 3 cycles of neoadjuvant platinum-based chemotherapy. Swift
initiation of immunosuppressive therapy with corticosteroids combined
with plasmapheresis did not result in significant clinical benefit.
Early recognition of this debilitating condition and standardization of
its treatment strategy are prerequisites for both improved survival
outcomes and quality of life in these patients. Further studies are
warranted to clarify the immune-stimulating impact of effective
cytotoxic chemotherapy and the occurence of autoimmune paraneoplastic
neurological syndromes.
(EN)
